Tumor
In order to clarify and detail the results of light and electron microscopy giagntokletochnyh tumors, chondro we developed the program for the morphometric studies were performed. For a more in-depth analysis degree of vascularization of tissue examined bone disease was carried out counting the percentage of area of the visual field occupied by vascular lumen to the area of tissue, free of vascular elements, that is supplied with blood vessels of these. The most significant differences in the intensity of blood flow observed in the comparison of benign giant cell tumors and malignancy. In benign giant cell tumor of the total area occupied by vessels of 8% to 92% of the tumor tissue. If malignancy was detected expressed more than fivefold increase in the area of vessels – 42% to 58% of the tumor tissue.
In the area occupied by vessels chondroma of 11% to 89% of the tumor tissue. In chondrosarcoma showed a significant increase in blood flow, as reflected in 33% of the area occupied by vascular elements. This is three times higher than the benign variant of vascularization. Accordingly, the area of tissue supplied with blood vessels decreased from 89% to 67% chondroma in chondrosarcoma. Identified differences of degree vascularization of tissue in the study of pathological processes, most clearly illustrates the vascularization index (IV). It is an integrative parameter, showing the average area of the lumen of blood vessels in the square microns per 1 square micron area of tissue.
Based on the results of the morphometric study of vascularization index was determined for all variants studied bone disease. In benign chondroma vascularization index was 0.31, and 0.72 for their malignancy, we have observed its increase by 2.3 times. However, the most pronounced difference in the degree of blood supply, we have identified with malignancy osteoblastoklastom who had revascularization index 25.8, that is 25 times greater than those of benign variants. Analysis of the data clearly shows that malignancy is uniquely in all groups disease is accompanied by increased vascularization index, in other words increasing the area of tissue occupied by vessels. In most of these changes are expressed in the malignant transformation of giant cell tumor and the least – for chondroma. Consequently, one of the objective indicators of malignancy of the investigated tumors can safely assume the quantitative parameters of tissue vascularization, and in our data, the most appropriate measure is the index of vascularization. That is, it reflects changes in the vasculature, regardless of size and shape of the vessels. In summary, we can say with confidence undoubted importance and priority of a comprehensive study of the extent and characteristics of tumor vasculature and tumor bone disease in order to highlight on this basis, the new diagnostic criteria biological activity – malignant neoplasm. The rapid growth of poorly differentiated tumor tissue is accompanied by active vascularization. This, in turn, determines the need for further and objective in dealing with complex diagnostic problems in modern clinical oncology. Working in the garden
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